PEGylated Polylactide Micelles for Controlled Drug Delivery
نویسندگان
چکیده
منابع مشابه
Stereocomplex-Reinforced PEGylated Polylactide Micelle for Optimized Drug Delivery
The instability of PEGylated polylactide micelles is a challenge for drug delivery. Stereocomplex interaction between racemic polylactide chains with different configurations provides an effective strategy to enhance the stability of micelles as the nanocarriers of drugs. In this work, a stereocomplex micelle (SCM) self-assembled from the amphiphilic triblock copolymers comprising poly(ethylene...
متن کاملHydrazone-Containing Triblock Copolymeric Micelles for pH-Controlled Drug Delivery
In this study, the structure-activity relationship of amphiphilic block copolymer micelles as nanosized drug delivery system was revealed. Firstly, a biodegradable triblock polymers PEG-DiHyd-PLA containing hydrazone bond was synthesized through the ring-opening polymerization. In this method, PEG-DiHyd-Phenol was used as the initiator and L-lactide as the monomer. Then, the polymeric micelles ...
متن کاملPolymer Micelles for Drug Delivery
Polymeric micelles obtained from the self-assembly of amphiphilic block copolymers are probably one of the most common drug delivery carriers among polymeric nanoparticles.1–4 The rise of highly controlled polymerization techniques, especially processes such as ATRP5 and RAFT,6 has led to an extraordinary surge of new types of block copolymers fit for biomedical applications. Facile control ove...
متن کاملPEGylated Silk Nanoparticles for Anticancer Drug Delivery.
Silk has a robust clinical track record and is emerging as a promising biopolymer for drug delivery, including its use as nanomedicine. However, silk-based nanomedicines still require further refinements for full exploitation of their potential; the application of "stealth" design principals is especially necessary to support their evolution. The aim of this study was to develop and examine the...
متن کامل19 Polymer Micelles for Drug Delivery
Polymer micelles have been used widely in the delivery of various therapeutic drugs, which are also known as active pharmaceutical ingredients (APIs). Recent advances in drug discovery technology, including an accumulated database on therapeutic targets, combinational chemistry, and high-throughput screening (HTS), have further increased the number of candidate compounds and constructed a huge ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Drug
سال: 2017
ISSN: 2514-4162
DOI: 10.24218/jod.2017.8